ニシムラ　ナオキ   NISHIMURA, Naoki   西村　直記 スポーツ科学部 スポーツ科学科 教授
言語種別	英語
発行・発表の年月	2026/08
形態種別	学術雑誌
査読	査読あり
標題	Effect of coffee bean chlorogenic acid on peripheral skin temperature and skin blood flow in healthy Japanese women with cold sensitivity: a placebo-controlled, randomized, double-blind, study
執筆形態	共同
掲載誌名	SPRINGER NATURE
掲載区分	国外
出版社・発行元	Trials
担当区分	最終著者
著者・共著者	Tomoko Nomura1, Yukinori Nakashima, Kazuya Kozuma, Akane Suma, Kazuhiko Higuchi, Naoki Nishimura
概要	In this study, we investigated the acute effects of a single dose of CGA on peripheral SkT and SkBF in a cold environment.This randomized, double-blind, placebo-controlled, crossover study was conducted from February to March 2018. Twenty-three healthy Japanese women with cold sensitivity were randomly assigned to the CGA (270 mg) or the Placebo group in a crossover study with a one-week washout period (11 took CGA first and 12 took the Placebo first). Peripheral SkT (primary outcome) and SkBF (secondary outcome) were evaluated in a moderate cold environment (22°C). The study was registered with the University Hospital Medical Information Network Clinical Trials Registry.Twenty-one participants completed all crossover periods. The crossover analysis approach showed a significant period effect for SkT (p = 0.002) and therefore, only the first period data were analyzed. Coffee bean CGA significantly suppressed the decrease in SkT (LS mean difference 0.45 °C, 95% confidence interval 0.02 to 0.87, p = 0.039) and SkBF (LS mean difference 0.45 a.u., 95% confidence interval 0.04 to 0.88, p = 0.032) during cold exposure. No adverse events attributed to the test beverage were observed. These results suggested that coffee bean CGA could suppress the decrease in SkT and SkBF in a cold environment.