|発表テーマ||Physical frailty and age-related body composition modifications|
|発表学会名||International conference on frailty & sarcopenia research2019|
|主催者||International conference on frailty & sarcopenia research|
|開催地名||Miami Beach, USA|
Age-related loss of muscle mass and strength, known as sarcopenia, is an important cause of physical dysfunctions such as
falling, fracture, frailty, including cardiovascular disease. However, the underlying contribution of sarcopenia to the development
of atherosclerosis is unclear.
This study was aimed to clarify the association of skeletal muscle mass index(SMI) and atherosclerosis, measured by the
cardio-ankle vascular index(CAVI) and ankle-brachial pressure index(ABI).
The Study was performed in 96 frail older persons. Data were collected by questionnaires and specific tests; demographic,
health characteristics, body mass index and body composition measured by the bioelectrical impedance analysis, CAVI, ABI,
the Mini-Nutritional Assessment, handgrip strength(GS), and walking speed. A Multiple regression analysis with multiple
imputation were performed to examine the association of atherosclerosis with SMI.
The Multiple regression analysis adjusted by conventional, nutritional, and anthropometric parameters showed that SMI was
independently associated with CAVI(B -0.87, 95% CI -1.60, -0.14, p=0.02).
Higher CAVI are significantly related to lower SMI in frail older people , even after adjusted by ABI, and other multiple factors.
The present results suggested that decline in skeletal muscle mass was associated with arterial stiffness rather than stenosis.